Reduced fimbria-associated activities of Porphyromonas gingivalis induced by recombinant fimbrial expression
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چکیده
منابع مشابه
Environmental regulation of fimbrial gene expression in Porphyromonas gingivalis.
Porphyromonas gingivalis fimbriae are an important virulence factor involved in attachment and invasion. Fimbrillin, encoded by the fimA gene, is the major subunit protein of the fimbriae. To elucidate the influence of environmental signals on the expression of the fimA gene, a strain of P. gingivalis (designated PLE) containing a chromosomal transcriptional fusion between a promoterless lacZ g...
متن کاملIsolation and characterization of a minor fimbria from Porphyromonas gingivalis.
We have discovered two distinctly different fimbriae expressed by the same Porphyromonas gingivalis strain. The construction of a fimA mutant of P. gingivalis ATCC 33277 has previously been reported by N. Hamada et al. (Infect. Immun. 62:1696-1704, 1994). Expression of fimbriae on the surface of the fimA mutant and the wild-type strain, ATCC 33277, were investigated by electron microscopy. The ...
متن کاملHost adhesive activities and virulence of novel fimbrial proteins of Porphyromonas gingivalis.
The fimbriae of Porphyromonas gingivalis mediate critical roles in host colonization and evasion of innate defenses and comprise polymerized fimbrilin (FimA) associated with quantitatively minor accessory proteins (FimCDE) of unknown function. We now show that P. gingivalis fimbriae lacking FimCDE fail to interact with the CXC-chemokine receptor 4 (CXCR4), and bacteria expressing FimCDE-deficie...
متن کاملStructural and functional studies of Porphyromonas gingivalis fimbrial proteins
Porphyromonas gingivalis expresses two forms of fimbriae, FimA and Mfa1. Each fimbria consists of five proteins; FimA-E and Mfa1-5. While the assembly of the type-1 fimbriae from Escherichia coli is well studied; the chaperone-usher pathway, very little is known about the polymerization of P. gingivalis fimbriae. The P. gingivalis fimbrial proteins form lipidated precursors that have an N-termi...
متن کاملFimbria-dependent activation of cell adhesion molecule expression in Porphyromonas gingivalis-infected endothelial cells.
Porphyromonas gingivalis is an oral pathogen that has recently been associated with chronic inflammatory diseases such as atherosclerosis. The strength of the epidemiological associations of P. gingivalis with atherosclerosis can be increased by the demonstration that P. gingivalis can initiate and sustain growth in human vascular cells. We previously established that P. gingivalis can invade a...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 2001
ISSN: 0378-1097
DOI: 10.1016/s0378-1097(01)00013-1